I say no. I believe that only beings with souls can wield Weapons, Hunter Axes, etc. It has already been stated that pairs must have compatible Wavelengths in order for a Weapon to even be wield. Such is the case when Black Star attempted to wield Soul.
Of course, this is only my opinion. However, never is it shown or stated in the material of SE that this is possible. This should add quite a bit of weight to my opinion. The only case for Soulless beings wielding Weapons that comes close, is the case of the Golem(A Souless Being) whom was capable of wielding Giriko. Later though, it is was revealed that the Golem held Arachne's Soul within it so that pretty much solves itself.